A case of ofloxacin-induced anaphylaxis mediated by non-IgE mediated, but a IgG4 mediated basophil activation mechanism
نویسندگان
چکیده
Background Ofloxacin is a second-generation fluoroquinolone that frequently has been prescribed against various bacterial infections. Serious hypersensitivity reactions will increase with high worldwide consumption. There have been few case reports of ofloxacin induced anaphylaxis and its pathogenic mechanism is not well understood. In this study, we investigated pathogenic mechanisms in a 20-year old female patient with ofloxacin induced anaphylaxis. She had suffered from allergic rhinitis sensitive to house dust mites for several years and a previous history of acute urticaria induced by non-steroidal antiinflammatory drugs. She developed generalized urticaria and anaphylaxis after oral ingestion of ofloxacin.
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